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Article

Secreted Factors From Proinflammatory Macrophages Promote an Osteoblast-Like Phenotype in Valvular Interstitial Cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2020

Grim Joseph C, Aguado Brian A, Vogt Brandon J, Batan Dilara, Andrichik Cassidy L, Schroeder Megan E, Gonzalez-Rodriguez Andrea, Yavitt F Max, Weiss Robert M, Anseth Kristi S

Abstract excerpt

OBJECTIVE: Resident valvular interstitial cells (VICs) activate to myofibroblasts during aortic valve stenosis progression, which further promotes fibrosis or even differentiate into osteoblast-like cells that can lead to calcification of valve tissue. Inflammation is a hallmark of aortic valve stenosis, so we aimed to determine proinflammatory cytokines secreted from M1 macrophages that give rise to a transient...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32938214
DOI: 10.1161/ATVBAHA.120.315261
PMCID: PMC7578003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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