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Article

Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2009

Yip Cindy Ying Yin, Chen Jan-Hung, Zhao Ruogang, Simmons Craig A

Abstract excerpt

OBJECTIVE: Extensive remodeling of the valve ECM in calcific aortic valve sclerosis alters its mechanical properties, but little is known about the impact of matrix mechanics on the cells within the valve interstitium. In this study, the influence of matrix stiffness in modulating calcification b...

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Identifiers

PMID: 19304575
DOI: 10.1161/ATVBAHA.108.182394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19304575-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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