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Article

Th1 cells reduce the osteoblast-like phenotype in valvular interstitial cells by inhibiting NLRP3 inflammasome activation in macrophages.

Molecular medicine (Cambridge, Mass.) - 30 Jul 2024

Lu Jing, Meng Jiaming, Wu Gang, Wei Wulong, Xie Huabao, Liu Yanli

Abstract excerpt

BACKGROUND AND AIMS: Inflammation is initiates the propagation phase of aortic valve calcification. The activation of NLRP3 signaling in macrophages plays a crucial role in the progression of calcific aortic valve stenosis (CAVS). IFN-γ regulates NLRP3 activity in macrophages. This study aimed to explore the mechanism of IFN-γ regulation and its impact on CAVS progression and valve interstitial cell...

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Share to Aortic Valve
Share to Aortic Valve Stenosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to NLR Family, Pyrin Domain-Containing 3 Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 39080527
DOI: 10.1186/s10020-024-00882-z
PMCID: PMC11287975

Genes

NLRP3
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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