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Article

High-mobility group box-1 protein induces osteogenic phenotype changes in aortic valve interstitial cells.

The Journal of thoracic and cardiovascular surgery - 1 Jan 2016

Wang Bo, Li Fei, Zhang Chao, Wei Guangxia, Liao Pingping, Dong Nianguo

Abstract excerpt

OBJECTIVES: Calcific aortic valve (AV) disease is known to be an inflammation-related process. High-mobility group box-1 (HMGB1) protein and Toll-like receptor 4 (TLR4) have been reported to participate in several inflammatory diseases. The purpose of the present study was to determine whether the HMGB1-TLR4 axis is involved in calcific AV disease, and to evaluate the effect of HMGB1, and its potential...

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Share to Aortic Valve
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26515875
DOI: 10.1016/j.jtcvs.2015.09.077

Genes

HMGB1
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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