Article
Interferons Are Pro-Inflammatory Cytokines in Sheared-Stressed Human Aortic Valve Endothelial Cells.
International journal of molecular sciences - 30 Sept 2021
Parra-Izquierdo Iván, Sánchez-Bayuela Tania, López Javier, Gómez Cristina, Pérez-Riesgo Enrique, San Román J Alberto, Sánchez Crespo Mariano, Yacoub Magdi, Chester Adrian H, García-Rodríguez Carmen
Abstract excerpt
Calcific aortic valve disease (CAVD) is an athero-inflammatory process. Growing evidence supports the inflammation-driven calcification model, mediated by cytokines such as interferons (IFNs) and tumor necrosis factor (TNF)-α. Our goal was investigating IFNs' effects in human aortic valve endothelial cells (VEC) and the potential differences between aortic (aVEC) and ventricular (vVEC) side cells. The endothelial...
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