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Article

Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2020

Raddatz Michael A, Huffstater Tessa, Bersi Matthew R, Reinfeld Bradley I, Madden Matthew Z, Booton Sabrina E, Rathmell W Kimryn, Rathmell Jeffrey C, Lindman Brian R, Madhur Meena S, Merryman W David

Abstract excerpt

OBJECTIVE: Macrophages have been described in calcific aortic valve disease, but it is unclear if they promote or counteract calcification. We aimed to determine how macrophages are involved in calcification using the Notch1+/- model of calcific aortic valve disease. Approach and Results: Macrophages in wild-type and Notch1+/- murine aortic valves were characterized by flow cytometry. Macrophages in Notch1+/-...

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Share to Aortic Valve
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Marrow Transplantation

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Share to Receptor, Notch1

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Identifiers

PMID: 32295422
DOI: 10.1161/ATVBAHA.120.314360
PMCID: PMC7285853

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