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Article

Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.

Journal of molecular and cellular cardiology - 1 May 2016

Hjortnaes Jesper, Goettsch Claudia, Hutcheson Joshua D, Camci-Unal Gulden, Lax Lilian, Scherer Katrin, Body Simon, Schoen Frederick J, Kluin Jolanda, Khademhosseini Ali, Aikawa Elena

Abstract excerpt

PURPOSE: Calcific aortic valve disease (CAVD) is the most prevalent valve disease in the Western world. Recent difficulty in translating experimental results on statins to beneficial clinical effects warrants the need for understanding the role of valvular interstitial cells (VICs) in CAVD. In two-dimensional culture conditions, VICs undergo spontaneous activation similar to pathological differentiation, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26996755
DOI: 10.1016/j.yjmcc.2016.03.004
PMCID: PMC4906202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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