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Article

The shift of macrophages toward M1 phenotype promotes aortic valvular calcification.

The Journal of thoracic and cardiovascular surgery - 1 Jun 2017

Li Geng, Qiao Weihua, Zhang Wenjing, Li Fei, Shi Jiawei, Dong Nianguo

Abstract excerpt

OBJECTIVE: The purpose of the present study was to comprehensively compare the phenotype profile of infiltrated macrophages in human noncalcified and calcific aortic valves, and to determine whether the shift of macrophage polarization modulates valvular calcification in vitro. METHODS: Cell surface markers of macrophages and inflammatory cytokines expression in 90 cases of human noncalcified and calcific aortic...

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PMID: 28283241
DOI: 10.1016/j.jtcvs.2017.01.052

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