Article

Macrophages Promote Aortic Valve Cell Calcification Through STAT3 Splicing

2020-01-24

Abstract excerpt

<h4>Objective</h4> Macrophages have been described in calcific aortic valve disease, but it is unclear if they promote or counteract calcification. We aimed to determine how macrophages are involved in calcification using the Notch1 +/- model of calcific aortic valve disease. <h4>Approach and Results</h4> Macrophages in wild-type and Notch1 +/- murine aortic valves were characterized by flow cytometry. Macrop...

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Literature Corpus work: fc2490e6-fe8a-56f9-b574-03b00015ea74
DOI: 10.1101/2020.01.24.919001

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