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Article

The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function.

Cell reports - 15 Sept 2020

Wirianto Marvin, Yang Jiah, Kim Eunju, Gao Song, Paudel Keshav Raj, Choi Jong Min, Choe Jeehwan, Gloston Gabrielle F, Ademoji Precious, Parakramaweera Randika, Jin Jianping, Esser Karyn A, Jung Sung Yun, Geng Yong-Jian, Lee Hyun Kyoung, Chen Zheng, Yoo Seung-Hee

Abstract excerpt

FBXL21 is a clock-controlled E3 ligase modulating circadian periodicity via subcellular-specific CRYPTOCHROME degradation. How FBXL21 regulates tissue-specific circadian physiology and what mechanism operates upstream is poorly understood. Here we report the sarcomere component TCAP as a cytoplasmic substrate of FBXL21. FBXL21 interacts with TCAP in a circadian manner antiphasic to TCAP accumulation in skeletal...

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Identifiers

PMID: 32937135
DOI: 10.1016/j.celrep.2020.108140
PMCID: PMC8299398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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