Article
A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System.
International journal of molecular sciences - 21 Feb 2022
Confino Shir, Dor Talya, Tovin Adi, Wexler Yair, Ben-Moshe Livne Zohar, Kolker Michaela, Pisanty Odelia, Park Sohyun Kathy, Geyer Nathalie, Reiter Joel, Edvardson Shimon, Mor-Shaked Hagar, Elpeleg Orly, Vallone Daniela, Appelbaum Lior, Foulkes Nicholas S, Gothilf Yoav
Abstract excerpt
The circadian clock, which drives a wide range of bodily rhythms in synchrony with the day-night cycle, is based on a molecular oscillator that ticks with a period of approximately 24 h. Timed proteasomal degradation of clock components is central to the fine-tuning of the oscillator's period. FBXL3 is a protein that functions as a substrate-recognition factor in the E3 ubiquitin ligase complex, and was...
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