Article

Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset

2022-07-22

Abstract excerpt

Ubiquitin-proteasome system (UPS) dysfunction is associated with the pathology of a wide range of human diseases including myopathies and muscular atrophy. However, the mechanistic understanding of specific components on the regulation of protein turnover during development and disease progression in skeletal muscle is unclear. Mutations in KLHL40 , an E3 ubiquitin ligase cullin3 (CUL3) substrate-specific adapter...

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Literature Corpus work: 8e5626d8-d132-543b-ba9f-77239c10d9c9
DOI: 10.1101/2022.07.21.501000

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