Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.

The Biochemical journal - 15 Oct 2016

Teixeira Felipe Roberti, Randle Suzanne J, Patel Shachi P, Mevissen Tycho E T, Zenkeviciute Grasilda, Koide Tie, Komander David, Laman Heike

Abstract excerpt

Fbxo7 is a clinically relevant F-box protein, associated with both cancer and Parkinson's disease (PD). Additionally, SNPs within FBXO7 are correlated with alterations in red blood cell parameters. Point mutations within FBXO7 map within specific functional domains, including near its F-box domain and its substrate recruiting domains, suggesting that deficiencies in SCFFbxo7/PARK15 ubiquitin ligase activity are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Neoplasm
Share to F-Box Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3 beta

Share to Inhibitor of Apoptosis Proteins

Share to Mitochondrial Precursor Protein Import Complex Proteins

Share to SKP Cullin F-Box Protein Ligases

Share to TNF Receptor-Associated Factor 2

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 27503909
DOI: 10.1042/BCJ20160387
PMCID: PMC5260939

Genes

FBXO7
TNF
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.PMID 27503909Read ↗

Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins.Semantic proximity Read ↗

Structure and Function of Fbxo7/PARK15 in Parkinson's Disease.Semantic proximity Read ↗

The role of FBXO7 in mitochondrial biology and Parkinson's diseaseSemantic proximity Read ↗

A new mutation in the Parkinson's-related FBXO7 gene impairs mitochondrial and proteasomal function.Semantic proximity Read ↗

Structural basis for regulation of the proteasome 20S core particle by the Parkinsonism-associated proteins FBXO7 and PI31Semantic proximity Read ↗

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.Semantic proximity Read ↗

FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivoSemantic proximity Read ↗

The parkinsonism-associated protein FBXO7 cooperates with the BAG6 complex in proteasome function and controls the subcellular localization of the complex.Semantic proximity Read ↗

Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism‐like phenotype in miceSemantic proximity Read ↗

FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provides a target for Pink1 phosphorylation <i>in vivo</i>Semantic proximity Read ↗

Ubiquitin and Parkinson's disease through the looking glass of geneticsSemantic proximity Read ↗

Functional characterization of FBXL7 as a novel player in human cancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.