Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases

26 Mar 2013

Abstract excerpt

The SCF (SKP1 (S-phase-kinase-associated protein 1), Cullin-1, F-box protein) E3 ubiquitin ligases, the founding member of Cullin-RING ligases (CRLs), are the largest family of E3 ubiquitin ligases in mammals. Each individual SCF E3 ligase consists of one adaptor protein SKP1, one scaffold protein cullin-1 (the first family member of the eight cullins), one F-box protein out of 69 family members, and one out of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to RNA modifications and cancer
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23528706
DOI: 10.1038/cr.2013.44

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligasesPMID 23528706Read ↗

Small RING Finger Proteins RBX1 and RBX2 of SCF E3 Ubiquitin Ligases: The Role in Cancer and as Cancer TargetsSemantic proximity Read ↗

RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27.Semantic proximity Read ↗

Cullin Family Proteins and Tumorigenesis: Genetic Association and Molecular MechanismsSemantic proximity Read ↗

F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospectsSemantic proximity Read ↗

F-Box Proteins and CancerSemantic proximity Read ↗

Cullin-RING Ligase 5: Functional characterization and its role in human cancersSemantic proximity Read ↗

Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism.Semantic proximity Read ↗

Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E.Semantic proximity Read ↗

F-box proteins at the crossroads of ubiquitination and tumor immunity: regulatory networks and immunotherapy strategiesSemantic proximity Read ↗

The emerging family of CULLIN3‐RING ubiquitin ligases (CRL3s): cellular functions and disease implicationsSemantic proximity Read ↗

Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice.Semantic proximity Read ↗

The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.