Article

YIPPEE/YPEL5 regulates circadian period by modulating PER ubiquitination and stability

2026-04-30

Abstract excerpt

Circadian clocks rely on evolutionarily conserved transcriptional–translational feedback loops to align physiology and behavior with the 24-hour day–night cycle. Post-translational modifications, especially ubiquitination, critically control core clock protein stability and circadian pace. In both fruit flies and mammals, the abundance of key pacemaker protein PERIOD (PER/PER2) must be tightly regulated to sustain...

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Literature Corpus work: aef2d091-a097-54ce-ad6e-387f526fc134
DOI: 10.64898/2026.04.28.721296

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