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Article

Polygenic risk for prostate cancer: Decreasing relative risk with age but little impact on absolute risk.

American journal of human genetics - 5 May 2022

Schaid Daniel J, Sinnwell Jason P, Batzler Anthony, McDonnell Shannon K

Abstract excerpt

Polygenic risk scores (PRSs) for a variety of diseases have recently been shown to have relative risks that depend on age, and genetic relative risks decrease with increasing age. A refined understanding of the age dependency of PRSs for a disease is important for personalized risk predictions and risk stratification. To further evaluate how the PRS relative risk for prostate cancer depends on age, we refined...

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Identifiers

PMID: 35353984
DOI: 10.1016/j.ajhg.2022.03.008
PMCID: PMC9118111

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