Article

CHD7 interacts with the nucleosome acidic patch for its efficient activity via its N-terminal region

2020-11-19

Abstract excerpt

Chromodomain-Helicase DNA binding protein 7 (CHD7) is an ATP dependent chromatin remodeler involved in maintaining open chromatin structure. Mutations of CHD7 gene causes multiple developmental disorders, notably CHARGE syndrome. However, there is not much known about the molecular mechanism by which CHD7 remodels nucleosomes. Here, we performed integrative biophysical analysis on CHD7 chromatin remodeler using cr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2b479cb9-1b90-549c-a619-317cc4d41958
DOI: 10.1101/2020.11.19.389429

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CHD7 interacts with the nucleosome acidic patch for its efficient activity via its N-terminal regionDOI 10.1101/2020.11.19.389429Read

A Novel N-terminal Region to Chromodomain in CHD7 is Required for the Efficient Remodeling Activity.Semantic proximity Read

Structure of the nucleosome-bound human BCL7ASemantic proximity Read

Acidic patch histone mutations and their effects on nucleosome remodeling.Semantic proximity Read

Nucleosome-CHD4 chromatin remodeller structure explains human disease mutationsSemantic proximity Read

Functional Insights into Chromatin Remodelling from Studies on CHARGE Syndrome.Semantic proximity Read

Chromatin remodeling by the CHD7 protein is impaired by mutations that cause human developmental disordersSemantic proximity Read

Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations.Semantic proximity Read

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaksSemantic proximity Read

Mechanistic insights into chromatin modulation by the “orphan” remodeler ATRXSemantic proximity Read

The Chd family of chromatin remodelers.Semantic proximity Read

Versatile Roles of the Chromatin Remodeler CHD7 during Brain Development and DiseaseSemantic proximity Read

Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tailsSemantic proximity Read