Article
Consequences of Stability-Induced Epistasis for Substitution Rates.
Molecular biology and evolution - 1 Nov 2020
Youssef Noor, Susko Edward, Bielawski Joseph P
Abstract excerpt
Do interactions between residues in a protein (i.e., epistasis) significantly alter evolutionary dynamics? If so, what consequences might they have on inference from traditional codon substitution models which assume site-independence for the sake of computational tractability? To investigate the effects of epistasis on substitution rates, we employed a mechanistic mutation-selection model in conjunction with a...
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