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Article

Epistasis in protein evolution.

Protein science : a publication of the Protein Society - 1 Jul 2016

Starr Tyler N, Thornton Joseph W

Abstract excerpt

The structure, function, and evolution of proteins depend on physical and genetic interactions among amino acids. Recent studies have used new strategies to explore the prevalence, biochemical mechanisms, and evolutionary implications of these interactions-called epistasis-within proteins. Here we describe an emerging picture of pervasive epistasis in which the physical and biological effects of mutations change...

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Identifiers

PMID: 26833806
DOI: 10.1002/pro.2897
PMCID: PMC4918427

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Source receipt: pubmed, retrieved 7 Sept 2026.

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