Factors controlling protein evolvability-at the molecular scale.

Abstract excerpt

This piece serves two purposes. Firstly, it aims to ascertain the extent to which the ‘principle of least action’ enables us to identify which of the potential pathways and trajectories leading to novel protein sequences have the highest evolutionary efficiency—in addition to examining how variations in factors such as protein robustness and folding rates (resulting from the inevitability of destabilizing...

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