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Article

Estimating the contribution of folding stability to nonspecific epistasis in protein evolution.

Proteins - 1 Dec 2018

Dasmeh Pouria, Serohijos Adrian W R

Abstract excerpt

The extent of nonadditive interaction among mutations or epistasis reflects the ruggedness of the fitness landscape, the mapping of genotype to reproductive fitness. In protein evolution, there is strong support for the importance and prevalence of epistasis but the quantitative and relative contribution of various factors to epistasis are poorly known. Here, we determine the contribution of selection for folding...

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Source

Identifiers

PMID: 30039542
DOI: 10.1002/prot.25588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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