Emergent time scales of epistasis in protein evolution.

Abstract excerpt

We introduce a data-driven epistatic model of protein evolution, capable of generating evolutionary trajectories spanning very different time scales reaching from individual mutations to diverged homologs. Our in silico evolution encompasses random nucleotide mutations, insertions and deletions, and models selection using a fitness landscape, which is inferred via a generative probabilistic model for protein...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Epistasis, Genetic
• Share to Evolution, Molecular