Exploring Evolution to Uncover Insights Into Protein Mutational Stability.

Abstract excerpt

Determining the impact of mutations on the thermodynamic stability of proteins is essential for a wide range of applications such as rational protein design and genetic variant interpretation. Since protein stability is a major driver of evolution, evolutionary data are often used to guide stability predictions. Many state-of-the-art stability predictors extract evolutionary information from multiple sequence...

Topics

• Protein Stability
• Evolution, Molecular
• Mutation
• Proteins
• Sequence Alignment
• Models, Genetic
• Thermodynamics