Origins and breadth of pairwise epistasis in an α-helix of β-lactamase TEM-1.

Abstract excerpt

The effect of mutations in a protein may depend on the presence of others-a phenomenon known as epistasis. Epistasis plays a key role in evolution and complicates predictions of mutational effects, as effects can be context-dependent. Yet, despite its importance, the mechanistic basis of epistasis remains poorly understood. To better characterize epistasis, we focused on an 11-residue α-helix in TEM-1 β-lactamase...

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• beta-Lactamases
• Epistasis, Genetic
• Escherichia coli
• Evolution, Molecular
• Models, Molecular