Article
Contingency and entrenchment in protein evolution under purifying selection.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 2015
Shah Premal, McCandlish David M, Plotkin Joshua B
Abstract excerpt
The phenotypic effect of an allele at one genetic site may depend on alleles at other sites, a phenomenon known as epistasis. Epistasis can profoundly influence the process of evolution in populations and shape the patterns of protein divergence across species. Whereas epistasis between adaptive substitutions has been studied extensively, relatively little is known about epistasis under purifying selection. Here...
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