Article
Epistatic drift causes gradual decay of predictability in protein evolution.
Science (New York, N.Y.) - 20 May 2022
Park Yeonwoo, Metzger Brian P H, Thornton Joseph W
Abstract excerpt
Epistatic interactions can make the outcomes of evolution unpredictable, but no comprehensive data are available on the extent and temporal dynamics of changes in the effects of mutations as protein sequences evolve. Here, we use phylogenetic deep mutational scanning to measure the functional effect of every possible amino acid mutation in a series of ancestral and extant steroid receptor DNA binding domains....
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