Article
Copy-Number Alteration Burden Differentially Impacts Immune Profiles and Molecular Features of Hepatocellular Carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2020
Bassaganyas Laia, Pinyol Roser, Esteban-Fabró Roger, Torrens Laura, Torrecilla Sara, Willoughby Catherine E, Franch-Expósito Sebastià, Vila-Casadesús Maria, Salaverria Itziar, Montal Robert, Mazzaferro Vincenzo, Camps Jordi, Sia Daniela, Llovet Josep M
Abstract excerpt
PURPOSE: Chromosomal instability is a hallmark of cancer that results in broad and focal copy-number alterations (CNAs), two events associated with distinct molecular, immunologic, and clinical features. In hepatocellular carcinoma (HCC), the role of CNAs has not been thoroughly assessed. Thus, we dissected the impact of CNA burdens on HCC molecular and immune features. EXPERIMENTAL DESIGN: We analyzed SNP array...
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