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Article

Heterogeneous immunogenomic features and distinct escape mechanisms in multifocal hepatocellular carcinoma.

Journal of hepatology - 1 May 2020

Dong Liang-Qing, Peng Li-Hua, Ma Li-Jie, Liu Dong-Bing, Zhang Shu, Luo Shu-Zhen, Rao Jun-Hua, Zhu Hong-Wen, Yang Shuai-Xi, Xi Shui-Jun, Chen Min, Xie Fan-Fan, Li Fu-Qiang, Li Wen-Hui, Ye Chen, Lin Li-Ya, Wang Yu-Jue, Wang Xiao-Ying, Gao Da-Ming, Zhou Hu, Yang Huan-Ming, Wang Jian, Zhu Shi-da, Wang Xiang-Dong, Cao Ya, Zhou Jian, Fan Jia, Wu Kui, Gao Qiang

Abstract excerpt

BACKGROUND & AIMS: The presence of multifocal tumors, developed either from intrahepatic metastasis (IM) or multicentric occurrence (MO), is a distinct feature of hepatocellular carcinoma (HCC). Immunogenomic characterization of multifocal HCC is important for understanding immune escape in different lesions and developing immunotherapy. METHODS: We combined whole-exome/transcriptome sequencing, multiplex...

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Share to Antigens, Neoplasm
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Lymphocytes, Tumor-Infiltrating

Share to Neoplasm Recurrence, Local

Share to Neoplasms, Multiple Primary

Share to Receptors, Antigen, T-Cell

Share to Tumor Escape

Source

Identifiers

PMID: 31887370
DOI: 10.1016/j.jhep.2019.12.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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