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Article

Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification.

Gut - 1 Jan 2023

Montironi Carla, Castet Florian, Haber Philipp K, Pinyol Roser, Torres-Martin Miguel, Torrens Laura, Mesropian Agavni, Wang Huan, Puigvehi Marc, Maeda Miho, Leow Wei Qiang, Harrod Elizabeth, Taik Patricia, Chinburen Jigjidsuren, Taivanbaatar Erdenebileg, Chinbold Enkhbold, Solé Arqués Manel, Donovan Michael, Thung Swan, Neely Jaclyn, Mazzaferro Vincenzo, Anderson Jeffrey, Roayaie Sasan, Schwartz Myron, Villanueva Augusto, Friedman Scott L, Uzilov Andrew, Sia Daniela, Llovet Josep M

Abstract excerpt

OBJECTIVE: We previously reported a characterisation of the hepatocellular carcinoma (HCC) immune contexture and described an immune-specific class. We now aim to further delineate the immunogenomic classification of HCC to incorporate features that explain responses/resistance to immunotherapy. DESIGN: We performed RNA and whole-exome sequencing, T-cell receptor (TCR)-sequencing, multiplex immunofluorescence and...

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Identifiers

PMID: 35197323
DOI: 10.1136/gutjnl-2021-325918
PMCID: PMC9395551

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