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Article

Expression landscape of epigenetic genes in human hepatocellular carcinoma

12 Jun 2025

Abstract excerpt

Hepatocellular carcinoma (HCC) is the most common primary liver tumor, often arising in the context of chronic liver disease. Despite recent advances in systemic therapies, including the use of immune checkpoint inhibitors (ICIs), clinical outcomes remain suboptimal, with many patients exhibiting primary or acquired resistance. Accumulating evidence indicates that the dysregulation of epigenetic mechanisms...

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PMID: 40504449
DOI: 10.1007/s13105-025-01095-6

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