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Article

Functional Genomic Complexity Defines Intratumor Heterogeneity and Tumor Aggressiveness in Liver Cancer.

Scientific reports - 15 Nov 2019

Kwon So Mee, Budhu Anuradha, Woo Hyun Goo, Chaisaingmongkol Jittiporn, Dang Hien, Forgues Marshonna, Harris Curtis C, Zhang Gao, Auslander Noam, Ruppin Eytan, Mahidol Chulabhorn, Ruchirawat Mathuros, Wang Xin Wei

Abstract excerpt

Chronic inflammation and chromosome aneuploidy are major traits of primary liver cancer (PLC), which represent the second most common cause of cancer-related death worldwide. Increased cancer fitness and aggressiveness of PLC may be achieved by enhancing tumoral genomic complexity that alters tumor biology. Here, we developed a scoring method, namely functional genomic complexity (FGC), to determine the degree of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 31729408
DOI: 10.1038/s41598-019-52578-8
PMCID: PMC6858353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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