Article
Characterization and validation of a preventative therapy for hypertrophic cardiomyopathy in a murine model of the disease.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2020
Viola Helena M, Shah Ashay A, Johnstone Victoria P A, Cserne Szappanos Henrietta, Hodson Mark P, Hool Livia C
Abstract excerpt
Currently there is an unmet need for treatments that can prevent hypertrophic cardiomyopathy (HCM). Using a murine model we previously identified that HCM causing cardiac troponin I mutation Gly203Ser (cTnI-G203S) is associated with increased mitochondrial metabolic activity, consistent with the human condition. These alterations precede development of the cardiomyopathy. Here we examine the efficacy of in vivo...
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