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Article

Molecular insights from a novel cardiac troponin I mouse model of familial hypertrophic cardiomyopathy.

Journal of molecular and cellular cardiology - 1 Oct 2006

Tsoutsman Tatiana, Chung Jessica, Doolan Alessandra, Nguyen Lan, Williams Iwan A, Tu Emily, Lam Lien, Bailey Charles G, Rasko John E J, Allen David G, Semsarian Christopher

Abstract excerpt

Gene mutations in cardiac troponin I (cTnI) account for up to 5% of genotyped families with familial hypertrophic cardiomyopathy (FHC). Little is known about how cTnI mutations cause disease. Five lines of transgenic mice were generated which overexpress the human disease-causing cTnI gene mutation, Gly203Ser (designated cTnI-G203S), in a cardiac-specific manner. Mice were compared to transgenic mice that...

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Source

Identifiers

PMID: 16950368
DOI: 10.1016/j.yjmcc.2006.07.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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