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Article

The L-type Ca(2+) channel facilitates abnormal metabolic activity in the cTnI-G203S mouse model of hypertrophic cardiomyopathy.

The Journal of physiology - 15 Jul 2016

Viola Helena, Johnstone Victoria, Cserne Szappanos Henrietta, Richman Tara, Tsoutsman Tatiana, Filipovska Aleksandra, Semsarian Christopher, Hool Livia

Abstract excerpt

KEY POINTS: Genetic mutations in cardiac troponin I (cTnI) are associated with development of hypertrophic cardiomyopathy characterized by myocyte remodelling, disorganization of cytoskeletal proteins and altered energy metabolism. The L-type Ca(2+) channel is the main route for calcium influx and is crucial to cardiac excitation and contraction. The channel also regulates mitochondrial function in the heart by a...

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Identifiers

PMID: 27062056
DOI: 10.1113/JP271681
PMCID: PMC4945708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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