uORFlight: a vehicle toward uORF-mediated translational regulation mechanisms in eukaryotes.

doi:10.1093/database/baaa007

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Article

uORFlight: a vehicle toward uORF-mediated translational regulation mechanisms in eukaryotes.

Database : the journal of biological databases and curation - 1 Jan 2020

Niu Ruixia, Zhou Yulu, Zhang Yu, Mou Rui, Tang Zhijuan, Wang Zhao, Zhou Guilong, Guo Sibin, Yuan Meng, Xu Guoyong

Abstract excerpt

Upstream open reading frames (uORFs) are prevalent in eukaryotic mRNAs. They act as a translational control element for precisely tuning the expression of the downstream major open reading frame (mORF). uORF variation has been clearly associated with several human diseases. In contrast, natural uORF variants in plants have not ever been identified or linked with any phenotypic changes. The paucity of such...

Topics

Animals
Caenorhabditis elegans
Data Mining
Databases, Genetic
Drosophila melanogaster
Eukaryota
Fungi
Genetic Variation
Humans
Internet
Open Reading Frames

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plants

Protein Biosynthesis

RNA, Messenger

Saccharomyces cerevisiae

Species Specificity

Vertebrates

Source

Open in PubMed Open full text

Identifiers

PMID: 32168374
DOI: 10.1093/database/baaa007
PMCID: PMC7068905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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