Article
Sex differences in CSF biomarkers vary by Alzheimer disease stage and APOE ε4 genotype.
Neurology - 27 Oct 2020
Babapour Mofrad Rosha, Tijms Betty M, Scheltens Philip, Barkhof Frederik, van der Flier Wiesje M, Sikkes Sietske A M, Teunissen Charlotte E
Abstract excerpt
OBJECTIVE: To evaluate sex differences in CSF biomarkers, taking the potential modifying role of clinical disease stage and APOE ε4 genotype into account. METHOD: We included participants (n = 1,801) with probable Alzheimer disease (AD) dementia (n = 937), mild cognitive impairment (MCI; n = 437), and subjective cognitive decline (SCD; n = 427). Main outcomes were CSF β-amyloid1-42 (Aβ42), total tau (t-Tau), and...
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