Sex Differences in the Relationship of Biomarker Change to Memory Decline in Early Alzheimer’s Disease: an Observational Cohort Study

Abstract excerpt

<title>Abstract</title> <p> Background Alzheimer’s disease (AD) exhibits sex differences in pathology and cognitive trajectories. Understanding how these differences manifest across the Alzheimer’s continuum can improve early detection, diagnostics, and interventions. We examined sex differences in how cerebrospinal fluid pTau181/Aβ42 ratio changes relate to verbal memory decline across the preclinical and mild...

Topics

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• Amyloid beta-Peptides
• Apolipoproteins E
• Neurofibrillary Tangles
• Peptide Fragments
• Phosphoproteins
• Plaque, Amyloid
• Sex Factors
• tau Proteins

Identifiers and source

Literature Corpus work

b7ee5410-aaf0-5323-abfe-b2b766d8cb52

DOI

10.21203/rs.3.rs-7661592/v1