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Article

Sex modifies the APOE-related risk of developing Alzheimer disease.

Annals of neurology - 1 Apr 2014

Altmann Andre, Tian Lu, Henderson Victor W, Greicius Michael D

Abstract excerpt

OBJECTIVE: The APOE4 allele is the strongest genetic risk factor for sporadic Alzheimer disease (AD). Case-control studies suggest the APOE4 link to AD is stronger in women. We examined the APOE4-by-sex interaction in conversion risk (from healthy aging to mild cognitive impairment (MCI)/AD or from MCI to AD) and cerebrospinal fluid (CSF) biomarker levels. METHODS: Cox proportional hazards analysis was used to...

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Source

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Identifiers

PMID: 24623176
DOI: 10.1002/ana.24135
PMCID: PMC4117990

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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