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Article

Sex influences the effects of APOE genotype and Alzheimer's diagnosis on neuropathology and memory.

Psychoneuroendocrinology - 1 Jul 2021

Duarte-Guterman Paula, Albert Arianne Y, Barha Cindy K, Galea Liisa A M, On Behalf Of The Alzheimer's Disease Neuroimaging Initiative

Abstract excerpt

Alzheimer's disease (AD) is characterized by severe cognitive decline and pathological changes in the brain (brain atrophy, hyperphosphorylation of tau, and deposition of amyloid-beta protein). Females have greater neuropathology (AD biomarkers and brain atrophy rates) and cognitive decline than males, however these effects can depend on diagnosis (amnestic mild cognitive impairment (aMCI) or AD) and APOE...

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Identifiers

PMID: 33962245
DOI: 10.1016/j.psyneuen.2021.105248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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