Single-cell transcriptomics-guided development of flow cytometric tests predicting chronic myeloid leukemia blast crisis transformation at chronic phase diagnosis

Abstract excerpt

Clinical risk scores in chronic myeloid leukemia (CML) are inadequate for identifying chronic phase (CP) patients at high-risk of blast crisis (BC) progression. The lack of accurate predictive tests hamper timely interventions, including stem cell transplants, that are more effective in early disease. By interrogating a single cell atlas of primary imatinib resistance for a BC-like gene expression signature, we id...

Topics

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• Blast Crisis
• Blood Proteins
• Chronic Myeloid Leukemia Treatments
• Clonal Evolution
• Core Binding Factor Alpha 2 Subunit
• Exome Sequencing
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive
• Oncogene Proteins, Fusion

Identifiers and source

Literature Corpus work

75cc9e1e-9c25-5afb-92de-eed9a271ac1c

DOI

10.1101/2025.01.09.632094