Article

Transcriptionally defined AML cell states associate with treatment response and microenvironmental remodeling

2026-07-01

Abstract excerpt

While therapy resistance in acute myeloid leukemia (AML) is often attributed to leukemic stem cells (LSCs), their functional properties are not fully captured by their well-established genetic landscape and cell lineage transcriptional programs. Here, we explore AML cell states and their associations to drug response and systemic immune context. We performed integrated single-cell transcriptomics and immunophenoty...

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Literature Corpus work: 197b6399-beb2-51e6-a874-9b244ab86476
DOI: 10.64898/2026.07.01.735780

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