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Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells

5 Aug 2020

Abstract excerpt

The blood-retina barrier and blood-brain barrier (BRB/BBB) are selective and semipermeable and are critical for supporting and protecting central nervous system (CNS)-resident cells. Endothelial cells (ECs) within the BRB/BBB are tightly coupled, express high levels of Claudin-5 (CLDN5), a junctional protein that stabilizes ECs, and are important for proper neuronal function. To identify novel CLDN5 regulators...

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PMID: 32759214
DOI: 10.1073/pnas.1911532117

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