Article

Derivation of functional retinal endothelial cells from human pluripotent stem cells for therapeutics and modeling

2025-03-10

Abstract excerpt

Retinal microvascular diseases involve a compromised inner blood-retina barrier (iBRB), which remains poorly understood. A renewable source of human iBRB endothelium is thus vital for advancing eye research and treatment development. Here, we differentiated human iPSCs into retinal endothelial cells (iRECs) via the Wnt/β-catenin pathway, namely Norrin/Frizzled4 signaling. These iRECs show genetic, protein, and fun...

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Literature Corpus work: 7bc7fd6a-0162-5893-b666-fa814ccb50b4
DOI: 10.1101/2025.03.04.641453

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