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Article

Endothelial Cell-Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact Vasculature.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2018

Zhang Chi, Lai Maria B, Pedler Michelle G, Johnson Verity, Adams Ralf H, Petrash J Mark, Chen Zhe, Junge Harald J

Abstract excerpt

Objective- Blood-CNS (central nervous system) barrier defects are implicated in retinopathies, neurodegenerative diseases, stroke, and epilepsy, yet, the pathological mechanisms downstream of barrier defects remain incompletely understood. Blood-retina barrier (BRB) formation and retinal angiogenesis require β-catenin signaling induced by the ligand norrin (NDP [Norrie disease protein]), the receptor FZD4...

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Identifiers

PMID: 30354230
DOI: 10.1161/ATVBAHA.118.311689
PMCID: PMC6221394

Genes

TSPAN12
FZD4
NDP
CDH5
LRP5

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