Article

Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cells

2021-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Endothelial cells (ECs) in the central nervous system (CNS) acquire their specialized blood-brain barrier (BBB) properties in response to extrinsic signals, with Wnt/β-catenin signaling coordinating multiple aspects of this process. Our knowledge of CNS EC development has been advanced largely by animal models, and human pluripotent stem cells (hPSCs) offer the opportunity to examine BBB develop...

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Literature Corpus work: 89cf6f4b-03ff-5df9-a910-defe62cfbeba
DOI: 10.1101/2021.05.12.443828

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