Article
DNGR1-Cre-mediated Deletion of Tnfaip3/A20 in Conventional Dendritic Cells Induces Pulmonary Hypertension in Mice.
American journal of respiratory cell and molecular biology - 1 Nov 2020
Koudstaal Thomas, van Hulst Jennifer A C, Das Tridib, Neys Stefan F H, Merkus Daphne, Bergen Ingrid M, de Raaf Michiel A, Bogaard Harm Jan, Boon Louis, van Loo Geert, Aerts Joachim G J V, Boomars Karin A, Kool Mirjam, Hendriks Rudi W
Abstract excerpt
Chronic perivascular inflammation is a prominent feature in the lungs of idiopathic pulmonary arterial hypertension. Although the proportions of conventional dendritic cells (cDCs) and plasmacytoid DCs are increased in idiopathic pulmonary arterial hypertension lungs, it remains unknown whether activated cDCs play a pathogenic role. The Tnfaip3 gene encodes the ubiquitin-binding protein A20, which is a negative...
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