Article
The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity.
Immunity - 22 Jul 2011
Kool Mirjam, van Loo Geert, Waelput Wim, De Prijck Sofie, Muskens Femke, Sze Mozes, van Praet Jens, Branco-Madeira Filipe, Janssens Sophie, Reizis Boris, Elewaut Dirk, Beyaert Rudi, Hammad Hamida, Lambrecht Bart N
Abstract excerpt
Dendritic cells (DCs) regulate both immunity and tolerance. Here we have shown that the ubiquitin editing enzyme A20 (Tnfaip3) determines the activation threshold of DCs, via control of canonical NF-κB activation. Tnfaip3(fl/fl)Cd11c-cre(+) mice lacking A20 in DCs demonstrated spontaneous proliferation of conventional and double-negative T cells, their conversion to interferon-γ (IFN-γ)-producing effector cells,...
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