Article
Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice.
International journal of molecular sciences - 10 Feb 2021
van Uden Denise, Koudstaal Thomas, van Hulst Jennifer A C, Bergen Ingrid M, Gootjes Chelsea, Morrell Nicholas W, van Loo Geert, von der Thüsen Jan H, van den Bosch Thierry P P, Ghigna Maria-Rosa, Perros Frédéric, Montani David, Kool Mirjam, Boomars Karin A, Hendriks Rudi W
Abstract excerpt
The pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) is not fully understood, but evidence is accumulating that immune dysfunction plays a significant role. We previously reported that 31-week-old Tnfaip3DNGR1-KO mice develop pulmonary hypertension (PH) symptoms. These mice harbor a targeted deletion of the TNFα-induced protein-3 (Tnfaip3) gene, encoding the NF-κB regulatory protein A20,...
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