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Article

Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis.

Nature immunology - 23 Oct 2011

Hammer Gianna Elena, Turer Emre E, Taylor Kimberly E, Fang Celia J, Advincula Rommel, Oshima Shigeru, Barrera Julio, Huang Eric J, Hou Baidong, Malynn Barbara A, Reizis Boris, DeFranco Anthony, Criswell Lindsey A, Nakamura Mary C, Ma Averil

Abstract excerpt

Dendritic cells (DCs), which are known to support immune activation during infection, may also regulate immune homeostasis in resting animals. Here we show that mice lacking the ubiquitin-editing molecule A20 specifically in DCs spontaneously showed DC activation and population expansion of activated T cells. Analysis of DC-specific epistasis in compound mice lacking both A20 and the signaling adaptor MyD88...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22019834
DOI: 10.1038/ni.2135
PMCID: PMC3419270

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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