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Article

SHARPIN is essential for cytokine production, NF-κB signaling, and induction of Th1 differentiation by dendritic cells.

PloS one - 1 Jan 2012

Wang Zhe, Sokolovska Anna, Seymour Rosemarie, Sundberg John P, Hogenesch Harm

Abstract excerpt

Spontaneous mutations of the Sharpin (SHANK-associated RH domain-interacting protein, other aliases: Rbckl1, Sipl1) gene in mice result in systemic inflammation that is characterized by chronic proliferative dermatitis and dysregulated secretion of T helper1 (Th1) and Th2 cytokines. The cellular and molecular mechanisms underlying this inflammatory phenotype remain elusive. Dendritic cells may contribute to the...

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Carrier Proteins
Cytokines
Dendritic Cells
Immunity
Inflammation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intracellular Signaling Peptides and Proteins

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Open in PubMed Open full text

Identifiers

PMID: 22348129
DOI: 10.1371/journal.pone.0031809
PMCID: PMC3279418

Genes

SHARPIN
MAPK1
MAPK11
TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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SHARPIN is essential for cytokine production, NF-κB signaling, and induction of Th1 differentiation by dendritic cells.PMID 22348129Read ↗

SHARPIN is a key regulator of immune and inflammatory responses.Semantic proximity Read ↗

Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.Semantic proximity Read ↗

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.Semantic proximity Read ↗

Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice.Semantic proximity Read ↗

Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell deathSemantic proximity Read ↗

Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.Semantic proximity Read ↗

Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice.Semantic proximity Read ↗

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.Semantic proximity Read ↗

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.Semantic proximity Read ↗

Ikaros cooperates with Notch activation and antagonizes TGFβ signaling to promote pDC development.Semantic proximity Read ↗

Linear ubiquitination prevents inflammation and regulates immune signalling.Semantic proximity Read ↗

Wiskott-Aldrich syndrome protein–mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cellsSemantic proximity Read ↗

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